Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
Article Abstract:
The understanding of the human central nervous system (CNS) is dependent on detailed knowledge of the molecular signals that control precusor cell migration and differentiation in humans. Molecular interactions that control cell migration and differentiation in the developing CNS can only be analyzed in vivo. Neural migration and differentiation data is vital for cell replacement strategy designs intended for treating human CNS disorders. An experimental version that allows the analysis of normal and disease-based human neurons and glia in an undisturbed CNS would help the facilitation of human CNS development, disease, and repair studies. Multipotential neural stem cells that are self-renewing can be isolated from the adult rodent and embryonic brain and produce the three main CNS cell types.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1998
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Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes
Article Abstract:
Neural stem cells (NSCs) are uncommitted, primordial cells that produce the assortment of central nervous system (CNS) cells that are more specialized. NSGs are operationally defined by their power to distinguish all neural lineages cells and to produce new NSCs that have the same possibilities. NSCs are also defined by their ability to populate CNS regions that are either developing or degenerating. What is mandatory in the definition is the showing of a monoclonal derivation of progeny. Rodent neural cells with stem cell properties can be reimplanted into the mammalian brain. In the brain, they can appropriately reintegrate and show foreign genes. Gene therapists and neurobiologists have started to analyze how to use this for therapeutic means.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1998
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A tissue of cells
Article Abstract:
Tissue engineering science is based on the recreation of vivo microenvironments ex vivo which in turn will enable us to recapitulate the biology needed to form and maintain complex tissues. There is a new method to recapitulate thymic development by engineering an artificial thymic "organoid."
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
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