Complementary therapies for inflammation

Article Abstract:

A study generates mice in which the native C5a receptor is replaced by its human counterpart and uses these animals to produce high-affinity monoclonal antibodies (mAbs) capable of preventing and reversing inflammation in a mouse model of rheumatoid arthritis. Antibodies against human C5aR generated using the knock-in strategy had IC50 values at least half those of the best in mAbs raised by a more conventional strategy involving use of C5aR-transferred cells as the immunogen.

United States, Care and treatment, Inflammation, Inflammation mediators

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Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

Article Abstract:

Humanized monoclonal antibody directed against complement component C5, eculizumab, is developed and shown to block proinflammatory and cytolytic effects of terminal complement activation. Approval of eculizumab as a first-in-class complement inhibitor for treating hemolytic disease paroxysmal nocturnal hemoglobinuria (PNH) validated the concept of complement inhibition as an effective therapy.

Description and travel, Shortness of breath, Dyspnea, Blood diseases, Hematologic diseases

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Arming antibodies: Prospects and challenges for immunoconjugates

Article Abstract:

Immunoconjugates, monoclonal antibodies (mAbs) coupled to highly toxic agents, including radioisotopes and toxic drugs, are becoming a significant component of anticancer treatments. It is described that by combining the exquisite targeting specificity of mAbs with the enhanced tumor-killing power of toxic side effects than most conventional chemotherapeutic drugs.

Antibody-drug conjugates, Antineoplastic antibiotics

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