Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
Article Abstract:
The development of therapeutic inhibitors of key signaling pathways is hampered by the inability to assess the effect of a particular drug on its target in the patient. An F(ab')(sub 2) fragment of the anti-HER2 antibody Herceptin with (Super 68)Ga, a position emitter, which allows the sequential positron-emission tomographic imaging of Her2 expression, is labeled.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes
Article Abstract:
A study is conducted to demonstrate that Epstein-Barr virus (EBV) specific T cells transduced with vectors encoding herpes simplex virus-1 thymidine kinase (HSV-TK) selectively accumulate radiolabeled FIAU. New technologies are needed to characterize the migration, survival and function of antigen-specific T cells in vivo.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
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Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo
Article Abstract:
The development of a targeted antisense approach to inhibit the dominant negative transcription factor ld1 in the tumor endothelium of living animals is reported.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2008
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