Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complimentary vectors
Article Abstract:
Splitting the adeno-associated virus (rAAV) vectors into two can increase the transduction efficiency and quantitation of the recombinant protein allowing for the development of gene therapy strategies with large cDNAs.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
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Robust expansion of human hepatocytes in [Fah.sup.-I-]/[Rag2.sup.-I-]/[II2rg.sup.-I-] mice
Article Abstract:
Severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice is generated in order to provide a useful hepatic xenorepopulation system. The expanded cells have exhibited typical human drug metabolism and this system has provided a robust platform for producing high-quality human hepatocytes for tissue culture, which is useful for testing the toxicity of drug metabolites.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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AAV vectors and tumorigenicity
Article Abstract:
Researchers have found that neonatal mice treated with recombinant adeno-associated viral (rAAV) vectors have higher incidence of hepatocellular carcinoma. Several incidences show that rAAV vectors contribute towards malignancy.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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