No longer lost in translation
Article Abstract:
Two in vivo real-time single molecule assays have shown that stochastic gene expression results in punctuated bursts of protein synthesis. The results have clarified the origins of fluctuations in gene expression and these methods are applicable to unfolding the complexities of gene networks and elucidating mechanisms of pathological gene expression.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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Climbing the protein ladder
Article Abstract:
A protein undergoes controlled acid digestion and creates two ladders on consisting of peptides containing N terminus and other containing C terminus. Analysis of the N terminal ladder of insulin by mass analysis of peptides is mentioned.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Protein sequencing by mass analysis of polypeptide ladders after controlled protein hydrolysis
Article Abstract:
Current techniques for determining protein modifications are not efficient. An approach for sequencing proteins and determining modifications with high speed, sensitivity and specificity is reported.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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