Polyclonal antibodies step out of the shadows
Article Abstract:
Biotech companies are addressing the problem of inability of monoclonals to address targets that mutate or require binding at multiple sites through two radically different approaches. The first and most advanced involves isolating the variable light and heavy (VL-VH) region of gene pairs from antibody-producing plasma cells and second involves the application of gene targeting/nuclear transfer technology in animals to replace partially or completely animal immunoglobulin genes with analogous genes from humans.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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GlaxoSmithKline cancer drug threatens Herceptin market
Article Abstract:
The first therapy for breast cancer, Genentech's Herceptin (trastuzumab), will face direct competition from GlaxoSmithKline (GSK) which is coming out with a novel drug GW 572016 (lapatinib), the only dual-action tyrosine kinase inhibitor in phase 3 trials. Lapatinib comes in the form of a tablet to be taken orally once a day, which can be also be used in combination with traditional chemotherapy and as a monotherapy, could supplant Herceptin.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Supreme Court boosts licensees in biotech patent battles
Article Abstract:
The impact of the U.S. Supreme Court's decision regarding the patents on the biotech industry, licensees and patent holders is discussed. The decision will be depending on how broadly lower courts interpret it in many of the patent lawsuits.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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