Interpreting DNA vibrational circular dichroism spectra using a coupling model from two-dimensional infrared spectroscopy
Article Abstract:
The experimentally derived coupling model is used to simulate and interpret the absorption and vibrational circular dichroism (VCD) spectra of several model double-stranded nucleic acids in the region of the nucleobase carbonyl stretches. It was found that VCD and absorption spectra for all the oligomers, poly(dG)-poly(dC), poly(dG-dC)-and dGGCC can be simulated within the uncertainties of the coupling model.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
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Inter and intrastrand vibrational coupling in DNA studied with heterodyned 2D-IR spectroscopy
Article Abstract:
Heterodyned 2D-IR, frequency resolved photon echo, and pump - probe spectroscopies were collected to study the couplings and anharmonicities of cytidine and guanosine bases in DNA. Cross-peaks between the G and C carbonyl bands that are interpreted as interstrand coupling across the two oligomers is observed, and strong intrastrand coupling between stacked G carbonyls is also presented.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2003
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DNA vibrational coupling revealed with two-dimensional infrared spectroscopy: Insight into why vibrational spectroscopy is sensitive to DNA structure
Article Abstract:
Two-dimensional infrared (2D IR) spectroscopy is applied to study the carbonyl vibrational modes of guanine and cytosine bases in A- and B-form DNA. The results have shown that the coupling is very strong for both hydrogen-bonded and stacked base geometries, creating vibrational modes that extend both across the base pairs and along the lengths of the helices.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
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