Calorimetry: a tool in the fight against heart disease

Article Abstract:

Differential scanning calorimetry (DSC) can be a tool in the fight against heart disease and lead to better understanding of atherosclerosis at the molecular level. Calorimetry can be used to study conformational changes that occur during thermally induced unfolding of lipid-free apo E isoforms. Thermodynamic data show differences between thermal stabilities of different isoforms which can be expressed in terms of differences in free energies of unfolding. Using isothermal titration calorimetry to study the lipid affinities of the exchangeable apolipoproteins apo A1 and A2 is also being researched to improve understanding of the preference of the apos mentioned for HDLs or very low density lipoproteins (LDLs).

Usage, Biochemistry, Equipment and supplies, Physiological aspects, Heart diseases, Apolipoproteins, Cytochemistry, High density lipoproteins, Low density lipoproteins, Cholesterol, Atherosclerosis, Calorimetry

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Rebels against the future

Article Abstract:

Technology and its relationship to corporate power is resented by many and feared by some. A global antitechnology and anti-free trade movement exists and, for some people, there is no evidence of any progress over the most recent 100 years or even the most recent 1000 years. A Teach-In on Technology and Globalization sponsored by the International Forum on Globalization (IFG) at Hunter College, New York City, February 24 and 25, 2001, is discussed. It focused on biotechnology and nanotechnology. The goal of the teach-in was to gather the leading critics of technologies, or Luddites.

Canada, World, Social aspects, Editorial, Statistical Data Included, Conferences, meetings and seminars, High technology industry, Political aspects, Science and technology policy, International economic relations, Science, Free trade, Luddites, International Forum on Globalization

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Ribonuclease H: a tool in the battle against leishmaniasis

Article Abstract:

A dissertation is presented on the effects of ribonuclease H (RNase H) on the parasitic disease leishmaniasis, which destroys the spleen and liver. RNase H mediates the lethality of phosphorothioate oligonucleotides in the protozoan Leishmania by killing RNase H overexpressing promastigotes and amastigotes.

Health aspects, Drug therapy, Ribonuclease, Parasitic diseases, Leishmaniasis, Leishmaniasis, Cutaneous, Cutaneous leishmaniasis

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