High-fat, high-cholesterol diet raises plasma HDL cholesterol: studies on the mechanism of this effect

Article Abstract:

A high-fat, high cholesterol (HF/HC) diet appears to raise levels of high-density-lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apo A-1) but is probably less healthy than a low fat, low cholesterol diet. High levels of HDL-C may reduce the risk of coronary heart disease. However, an HF/HC diet probably causes increases in HDL-C as a result of adapting to high lipid levels and causes greater translation of apo A-1 mRNA.

Dietary fat, Cholesterol

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The mechanism of uptake of ascorbic acid into osteoblasts and leukocytes

Article Abstract:

Two mechanisms exist for uptake of ascorbic acid by osteoblasts or leukocytes. For leukocytes, glucose transporter one is used by myeloid leukemia cells and neutrophils, to bring in dehydroascorbic acid. For osteoblasts, or other connective tissue cells such as fibroblasts, the other mechanism uses positively charged sodium to transort it into the cells. Both mechanisms increase the intracellular concentration of ascorbic acid.

Research, Biological transport, Vitamin C, Vitamin C metabolism, Vitamin metabolism, Physiological absorption, Absorption (Physiology)

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Leptin: the weight-reducing plasma protein encoded by the obese gene

Article Abstract:

Studies on the obese (ob) gene and its product, the leptin protein, have helped elucidate a system in which leptin acts as a hormone signal in the regulation of appetite and metabolism. Mice injected with leptin lost weight and ate less. Insulin stimulates ob gene activity. Leptin, which is produced in adipose tissue, may act as an indicator of the body's fat content by inhibiting neuropeptide Y release from the hypothalamus.

Leptin, Neuropeptide Y, Obesity gene

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