Iron and gene expression: molecular mechanisms regulating cellular iron homeostasis

Article Abstract:

Molecular mechanisms regulating cellular iron homeostasis have been related to gene expression. Specific post-transcriptional mechanisms in the cytoplasm of vertebrate cells have been elucidated. They directly affect stability and translation of mRNAs coding for central proteins in iron metabolism. Other levels of control likely exist and affect gene transcription and/or relate to function of transport across the cell membrane and iron-capturing substances. The newly found mechanisms involving iron regulatory proteins and signals that interfere with them are discussed.

Switzerland, Iron in the body, Iron (Nutrient), Gene expression, Cellular control mechanisms, Cell regulation, Messenger RNA

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Vitamin D polymorphisms and calcium homeostasis: a new concept of normal gene variants and physiological variation

Article Abstract:

Osteoporosis is related to a new concept of normal gene variants and physiological variation developed relative to vitamin D polymorphisms and calcium homeostasis. The genetics of osteoporosis has been related to targeting genetic studies, and genome scan approaches may be used in time. Relationships between environment, lifestyle, and genetics may be a topic for research in the future, and more specific treatments and better options may emerge.

Australia, Aging, Statistical Data Included, Usage, Bones, Bone density, Chromosome mapping, Osteoporosis, Vitamin D, Cell receptors, Genetic polymorphisms, Ethnic groups, Calcium, Calcium (Chemical element)

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Proteinuria and albumin homeostasis in the nephrotic syndrome: effect of dietary protein intake

Article Abstract:

Most patients with nephrotic syndrome will probably benefit best from a normal protein intake. Nephrotic syndrome is characterized by excessive protein excretion in the urine, hypoalbuminemia and edema. It is caused by damage to the glomerular basal membrane which then allows the passage of macromolecules. Research has shown that neither a low-protein or high-protein diet is beneficial in patients with nephrotic syndrome.

Albuminuria, Low-protein diet, Protein restricted diet, Nephrotic syndrome

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