Neuropeptides responding to leptin

Article Abstract:

Melanocortin appears to participate in one of the signaling pathways induced by leptin. Leptin is a protein that regulates food intake. It was thought to act via neuropeptide Y (NPY), but NPY-knockout mice exhibit normal feeding behavior and body weight. Research on the agouti mouse, which develops late-onset obesity, found a newly described melanocortin receptor called MC4-R. In agouti mice, the overexpression of the agouti protein blocks the action of melanocortin at this receptor.

Leptin, Neuropeptides

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Adipocyte differentiation is regulated by a prostaglandin liganded to the nuclear peroxisome proliferator-activated receptor

Article Abstract:

A nuclear receptor protein may be regulating the differentiation and homeostasis of adipocytes, or fat cells, in obese and diabetic people. Both the receptor and 15-deoxy-delta 12,14-prostaglandin, its endogenous ligand, may be working together in regulating glucose homeostasis and adipocyte differentiation. Supporting evidence in favor of such receptor activation comes from the antidiabetic drug thiazolidinedione which simulates internal prostaglandin action.

Hormone receptors, Glucose metabolism

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The molecular mechanism of the stimulation of adipocyte differentiation by a glucocorticoid

Article Abstract:

Glucocorticoid dexamethasone mediates the differentiation of preadipocytes to adipocytes by repressing the preadipose factor 1 gene.

United States, Dexamethasone, Hyperplasia

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