Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor
Article Abstract:
Folate receptors are connected to plasma membranes through a glycosylphosphatidylinositol connector. They must have both sphingolipids and cholesterol in the membrane to be fully active. Treatment of cells in culture with the mycotoxin fumonisin B1 essentially stopped uptake of 5-methyltetrahydrofolate. Fumonisin B1 inhibits sphingolipid synthesis.
Publication Name: Nutrition Reviews
Subject: Food/cooking/nutrition
ISSN: 0029-6643
Year: 1998
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Individual variability in homocysteine response to folate depletion: an unusual case
Article Abstract:
Elevated plasma homcysteine concentrations have been associated with an increased risk of vascular disease. This is cause by a variety of genetic and nutritional factors, the most influential is folate nutriture. The homocysteine response to folate can vary between individuals and further research is necessary.
Publication Name: Nutrition Reviews
Subject: Food/cooking/nutrition
ISSN: 0029-6643
Year: 1998
User Contributions:
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