Retinoid repletion of vitamin A-deficient mice restores IgG responses

Article Abstract:

Retinoid repletion studies were made on vitamin A-deficient (A-) mice to find out the most potent retinoid that restores immunoglobulin (IgG) response. Retinoic acid proved more potent than retinyl acetate, retinaldehyde and retinol in sustaining IgG synthesis. A minimum retinoic acid concentration of 0.01 nanomole per liter greatly raised the IgG response. Thus, retinoic acid seems to be the key metabolite maintaining the IgG system. A minimum of 4 micrograms of retinyl acetate per gram of mice diet suffices to keep the IgG system working.

Research, Immunoglobulin G, Retinoids, Vitamin A deficiency

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Incorporation of /3H~proline into collagen and other proteins in rats fed diets with various zinc concentrations

Article Abstract:

The effects of zinc restriction on the incorporation of liver and skin protein in protein-deprived weanling rats were studied. Observations show that the rats had a decreased hydroxyproline, or /3H~proline, incorporation into collagen and other skin proteins and an accompanying body weight loss. This suggests that zinc restriction may shift /3H~proline incorporation from skin proteins into liver and plasma proteins to make up for the weight loss. Dietary restriction produced the same results.

Proteins, Protein synthesis, Collagen, Amino acids

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Marginal zinc deficiency has no effect on primary or challenge infections in mice with Heligmosomoides polygyrus (Nematoda)

Article Abstract:

The effect of varying amounts of zinc on the immune response of mice against the intestinal parasite Heligmosomoides polygyrus infections was evaluated in primary infected and challenged hosts. Results indicated that zinc supplements did not impart a degree of immunity to mice because substantial supplements did not reduce infection. On the other hand, the parasite induced spleen growth, elevated copper levels in the spleen and the liver and reduced levels of iron in the spleen.

Physiological aspects, Parasitism

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