Temafloxacin: a safe antibiotic for the elderly, patients with comorbidities, and other special populations

Article Abstract:

Temafloxacin is a new type of antibiotic of the recently developed group known as fluoroquinolones. Clinical trials have shown temafloxacin to be effective against a wide range of gram-negative and gram-positive bacteria and to be well tolerated, causing few adverse side effects. The safety of temafloxacin was examined in special populations who are at greater risk for adverse drug effects. Temafloxacin was found to be as safe in the elderly, that is, patients 65 years and older, as in younger patients. Temafloxacin did not adversely interact with drugs often taken by the elderly, including warfarin, theophylline, caffeine and cimetidine. Low-dose temafloxacin therapy is recommended for elderly patients with severe renal disease, but smaller doses are not necessary in the treatment of patients who have mild kidney impairment. No problems were observed when patients other chronic diseases were treated with temafloxacin; chronic conditions that were investigated include diabetes, obstructive lung disease and liver disease. (Consumer Summary produced by Reliance Medical Information, Inc.)

Antibiotics, Bacterial infections

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Treatment of chronic bacterial prostatitis with temafloxacin

Article Abstract:

Prostatitis, or inflammation of the prostate gland, is one of the most common causes of recurring urinary tract infections in men. The effectiveness of temafloxacin, a new type of antibiotic of the fluoroquinolone group, in treating bacterial prostatitis was assessed in 81 men (average age 47 years). Temafloxacin has bactericidal activity against a wide variety of bacteria and is well tolerated by the body. It causes few adverse side effects. The most common bacteria causing prostatitis infections in this population of patients were Escherichia coli and Enterococcus. Clinical symptoms were alleviated in 91 percent of the patients (74 of 81). The bacteria were completely killed in 94 percent of the men. Adverse side effects involved the digestive system (6.3 percent of the patients) and the nervous system (4.5 percent). This study showed that temafloxacin is an effective treatment for chronic bacterial prostatitis in men. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Drug therapy, Urinary tract infections, Escherichia coli infections, Prostatitis

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