A MARCKS - related peptide blocks mucus hypersecretion in a mouse model of asthma

Article Abstract:

Myristeoylated, alanine - rich C - kinase substrate (MARCKS), a synthesized peptide, blocks the hyper secretion of mucus, an important feature of asthma. Intratracheal administration of MARCKS-related peptide could therapeutically reduce mucus secretion in the airways of human patients with asthma chronic bronchitis and cystic fibrosis.

Peptides, Bronchitis

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Cystic fibrosis salt/fluid controversy: In the thick of it

Article Abstract:

A new study shows that a mouse model of cystic fibrosis has lower levels of liquid on the surface of its airway epithelium. This suggests that thickened airway secretions might have a role in the disease process and that rehydrating the airways might be benefit to patients.

Epithelium

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Rules of conduct for the cystic fibrosis anion channel

Article Abstract:

The improper balance in the use of ion resulting into defects in the ion channel cystic fibrosis transmembrane conductance receptor(CFTR) is illustrated. The complete functioning of CFTR channel is now diagnosed and is cured.

Analysis, Ion channels

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