A dominant epitope of HIV-1 protease recognized by hamster monoclonal antibodies
Article Abstract:
Monoclonal antibodies against a protease produced by the human immunodeficiency virus type 1 (HIV-1) were able to recognize an enzyme component essential to the function of the protease. Proteases are enzymes that break down proteins. Armenian hamsters were inoculated with genetically-engineered HIV-1 protease. Three days later, their spleen cells were fused with a myeloma cell line to create monoclonal antibodies against the protease. Five of the antibodies produced by the hamsters reacted to a sequence of the protease close to the binding site for the substrate. If these antibodies can inhibit the protease, they may be useful in the development of therapeutic drugs which will inhibit the replication of the virus.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Clinical significance of HIV DNA in polymorphonuclear neutrophils from patients with HIV infection
Article Abstract:
DNA from the human immunodeficiency virus (HIV) was detected in the neutrophils of HIV-infected patients. Neutrophils are cells which play a part in immune responses. The breakdown of neutrophil activity is part of the process of infection with HIV. This decrease in functioning may play a role in the susceptibility of AIDS patients to diseases. Neutrophils were isolated from blood samples from 37 HIV-infected patients. HIV DNA was most often found in the neutrophils of patients who had symptoms of HIV infection. HIV DNA was found more often in patients with low blood levels of neutrophils. HIV DNA was also found more often in patients with Pneumocystis carinii pneumonia.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: General internal medicine and general internists: recognizing a national need. United we stand
- Abstracts: Beans can make you ... lean?! A matter of fat: confused by terminology? You needn't be. Eat fat to lose fat?
- Abstracts: The development of awareness of iron-withholding defense. The lactobacillus anomaly: total iron abstinence. Lactoferrin, lactoferrin receptors and iron metabolism
- Abstracts: Atherosclerotic renovascular disease and progressive renal failure. Detection of renovascular hypertension: state of the art - 1992
- Abstracts: Culture shock. The future for mental health nursing