A molecular link between the sudden infant death syndrom and the long-QT syndrome

Article Abstract:

Many cases of sudden infant death syndrome (SIDS) may be caused by a heart arrhythmia called the long-QT syndrome. In one study, half of the babies who died from SIDS had the long-QT syndrome. Babies with long-QT syndrome had 41 times the risk of SIDS compared to other babies. However, in many cases the parents have a normal heart rhythm. Researchers describe the case of a 44-day-old baby who almost died of SIDS. DNA analysis showed that he had a spontaneous mutation in the cardiac sodium channel gene.

Health aspects, Causes of, Sudden infant death syndrome, Arrhythmia in children, Pediatric cardiology

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Risk stratification in the long-QT syndrome

Article Abstract:

The symptoms and the prognosis of long-QT syndrome depend on which of three different genes is mutated, according to a study of 647 patients. Mutations in two different potassium channel genes and one sodium channel gene can cause long-QT syndrome, which is a heart arrhythmia. Mutation of the KCNQ1 potassium channel gene seems to have the best prognosis.

Mortality, Prognosis, Genetic aspects, Health risk assessment

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Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers

Article Abstract:

The outcomes in a large systematically genotyped population of beta-blocker-treated long QT syndrome(LQTS) patients are described and assessed. It is indicated that there is a high rate of cardiac events, particularly among patients with LQT2 and LQT3 genotypes.

United States, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Beta Blockers, Diagnosis, Heart diseases, Dosage and administration, Adrenergic beta blockers, Adrenergic beta-antagonists, Long QT syndrome

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