A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
Article Abstract:
The tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived from the breakdown of extracellular matrix (ECM), which shares sequence and structural homology with an important domain on alpha chemokines is described. PGP's activity links degradation of ECM with neutrophil recruitment in airway inflammation, and PGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Peptide-based therapeutic vaccines for allergic and autoimmune diseases
Article Abstract:
A study on the ability to modify antigen-specific pathogenic responses by therapeutic vaccination that offers the prospect of targeted therapy is carried out. Selection of appropriate antigens and peptides, optimization of peptide dose and route of administration and identifying strategies to induce bystander suppression are the challenges in the development of therapeutic vaccines.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Reply to 'A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation'
Article Abstract:
Evidence that the extracellular matrix-derived tripeptide Pro-Gly-Pro (PGP) is chemotactic for neutrophils by activating CXCR1 and CXCR2 receptors is provided. It is proposed that the tripepetide PGP elicits its function by mimicking the highly conserved 'GP' motif observed in native chemokine ligands for these receptors.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
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