A pilot study of intravenous ondansetron for hyperemesis gravidarum
Article Abstract:
The anti-vomiting drug ondansetron may be no more effective than promethazine in treating pregnant women hospitalized for excessive nausea and vomiting. Promethazine is the standard treatment for pregnancy-related vomiting. Researchers compared the effect of intravenous doses of ondansetron given to 15 patients to that of intravenous promethazine in 15 other patients. Patient self-reports, days of hospitalization, number of treatment doses, and side effects were similar for ondansetron and promethazine. Treatment response occurred after minimal doses of either medication. Patients also received intravenous hydration. Ondansetron is more expensive per dose than promethazine, and may not provide any more relief from excessive vomiting.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Experience with oral methylprednisolone in the treatment of refractory hyperemesis gravidarum
Article Abstract:
Methylprednisolone appears to be an effective treatment for hyperemesis gravidarum. This condition is characterized by severe and persistent vomiting during pregnancy. Researchers gave 18 pregnant women with hyperemesis gravidarum 48 milligrams of methylprednisolone every day for three days and then tapered the dose over the next two weeks. The drug was effective in 17 of the women, who were able to eat a regular diet within three days. Seven had no further symptoms after the drug was stopped but nine had to begin taking it again and seven stopped vomiting.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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The efficacy of methylprednisolone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study
Article Abstract:
Methylprednisolone may effectively treat hyperemesis gravidarum, excessive vomiting during pregnancy. Researchers compared methylprednisolone to promethazine in forty women who were up to 16 weeks pregnant. A two-week therapy of methylprednisolone effectively stopped vomiting whereas promethazine therapy failed to stop vomiting in 5 of 17 patients. Neither drug produced negative side effects.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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