In situ detection of virus- and tumor-specific T-cell immunity

Article Abstract:

This article describes in situ visualization of antigen-specific T-cell responses using tetrameric-major histocompatibility complex (MHC) complexes. Data are also presented on the detection of virus- and tumor-specific CD8+ T cells using a combination method comprising of MHC tetramer technology and confocal laser scanning microscopy.

Netherlands, Statistical Data Included, Usage, Testing, Identification and classification, Major histocompatibility complex, Lymphoid tissue, CD8 lymphocytes

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A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression

Article Abstract:

The development of a new rapid and potent intradermal DNA vaccination method is discussed. Humoral immunity against influenza A infection is provided by the vaccination strategy within two weeks after the start of vaccination.

DNA vaccines

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Vaccine leads to memory loss

Article Abstract:

Mouse models are used to show that a widely used approach to vaccine adjuvants, targeting of the CD40 receptor, might have an unexpected deleterious side-effect, as it abolishes long-term T-cell responsiveness toward tumor antigens. Researchers have provided evidence for the long-term effect of this vaccine adjuvant, where they show that the vaccination with antibody to CD40 can actually interfere with the long-term capacity for T-cell reactivity.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Immunostimulants, Immunomodulators, Immunoamplifiers, Causes of, Complications and side effects, Memory, Disorders of, Memory disorders, Immunologic adjuvants, CD4 lymphocytes, Tumor antigens, Tumour antigens, Immunological adjuvants

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