AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection
Article Abstract:
Feline immunodeficiency virus Maryland isolate (FIV-MD) may cause neurologic abnormalities similar to AIDS-associated encephalopathy in children. AIDS-associated encephalopathy is a degenerative disease of the brain. Among 12 eight-week-old kittens who were evaluated over a 16-month period, six were injected with FIV-MD and six (in the control group) were not. The infected kittens developed immunodeficiency and their growth was delayed. They also developed neurologic abnormalities characterized by repetitive and compulsive behavior as early as four weeks after infection. Three cats displayed this behavior throughout the 16-month follow-up period. Twelve months after infection, a magnetic resonance imaging (MRI) scan of the brains of infected cats revealed wasting of brain tissue and white matter lesions. Electroencephalography (EEG) and evoked potential tests were also performed to evaluate brain function. These electrodiagnostic tests were found to be more sensitive than MRI in detecting neurologic abnormalities caused by FIV-MD.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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Increase in percentage of CD45RO+/CD8+ cells is associated with previous severe primary HIV infection
Article Abstract:
HIV-positive people with more severe initial symptoms may experience a change in the proportion of certain types of cells. Researchers studied the proportions of naive and memory T cells in 43 HIV-positive people, some of whom had progressed to AIDS. The HIV-positive people whose illness started with severe symptoms were similar to AIDS patients in that their CD8 T cells showed a greater proportion of memory to naive cells. This finding suggests that HIV infection causes the number of naive and memory CD4 T cells to decrease, as well as the number of naive CD8 cells. Changes in proportions of naive and memory T cells could not be correlated to long term infection or speed of disease progression.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Progressive encephalopathy associated with CD4/CD8 inversion in adult FIV-infected cats
Article Abstract:
Feline immunodeficiency virus (FIV) infection in cats, a disease similar to HIV infection, causes progressive neurological disease as the ratio of CD4/CD8 lymphocytes falls. CD4 lymphocyte depletion with progressive disease may cause the onset of encephalopathy and neurological abnormalities.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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