Abnormal endothelial cell function of resistance arteries from women with preeclampsia

Article Abstract:

Endothelium-dependent blood vessel relaxation may be impaired in pregnant women suffering from preeclampsia. Preeclampsia is a condition occurring during late pregnancy that is characterized by hypertension, increased levels of protein in the urine and fluid collection. Sections of small arteries were surgically removed from 24 pregnant women during a cesarean section. Twelve were healthy and 12 had preeclampsia. Arteries from the pregnant women with preeclampsia did not relax normally after contraction, while those from the healthy women did. This could contribute to increased resistance to blood flow, which is a characteristic of preeclampsia.

Vasodilators, Vasodilator agents, Arteries

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Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia

Article Abstract:

Bradykinin may play a role the blood vessel dilation that occurs in normal pregnancy and the blood vessel constriction of preeclampsia. Researchers dissected out small arteries from tissue samples removed during cesarean section in 24 pregnant women with normal blood pressure, 6 women with preeclampsia, and 15 nonpregnant women having other abdominal surgery. Preconstricted arteries from pregnant women with normal blood pressure had an enhanced relaxation response when exposed to bradykinin compared with nonpregnant women. Women with preeclampsia showed a decreased response compared with pregnant women with normal blood pressure.

Bradykinin

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Longitudinal evaluation of markers of endothelial cell dysfunction and hemostasis in treated antiphospholipid syndrome and in healthy pregnancy

Article Abstract:

Research has been conducted on antiphospholipid syndrome pregnancies. The authors have investigated the hypothesis that these pregnancies are associated with endothelial cell activation in maternal circulation.

United Kingdom, Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Health aspects, Care and treatment, Research, Analysis, Prevention, Causes of, Genetic aspects, Genetic markers, Pregnancy, Antiphospholipid syndrome, Obstetrics, Hemostasis, Gynecological research

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