Adrenal insufficiency

Article Abstract:

Adrenal insufficiency can lead to death under stressful conditions unless properly treated. Deficient cortisol secretion in adrenal insufficiency is often caused by autoimmune conditions, such as adrenalitis, thyroid disease, tuberculosis, and AIDS. Patients with adrenal insufficiency report gastrointestinal symptoms, other non-specific signs, and excessive skin pigmentation. Several hormone function tests can diagnose the specifics of adrenal insufficiency. Drug treatment includes hydrocortisone or cortisone combined with single daily doses of fludrocortisone. Higher hydrocortisone doses are advised during periods of fever or injury.

Care and treatment, Methods, Measurement, Addison's disease, Pituitary-adrenal function tests

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Dehydroepiandrosterone for adrenal insufficiency

Article Abstract:

Dehydroepiandrosterone is a hormone produced by the adrenal glands. In most healthy people, blood levels of dehydroepiandrosterone are highest in the 20s, and then decrease to only 20% to 30% of those levels by the age of 70 or 80. People with adrenal insufficiency do not produce enough adrenal hormones, including dehydroepiandrosterone. A 1999 study found that dehydroepiandrosterone increased sexual well-being as well as overall mental health in women with adrenal insufficiency. It may also be useful in people with depression, postmenopausal osteoporosis, and those taking high doses of corticosteroids.

Editorial, Dehydroepiandrosterone

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Measurements of serum free cortisol in crtically ill patients

Article Abstract:

The effect of decreased amounts of cortisol-binding proteins on serum total free cortisol concentrations during critical illness, when glucocoriticoid secretion is maximally stimulated, is investigated. Measuring serum free cortisol concentrations in critically ill patients with hypoproteinemia may help prevent the unnecessary use of glucocorticoid therapy.

United States, Risk factors, Corticosteroids, Critically ill, Protein metabolism disorders, Glucocorticoids

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