Adrenoleukodystrophy
Article Abstract:
This report of medical rounds at Johns Hopkins Hospital presents a case study of a 35-year-old white man with adrenoleukodystrophy (ALD). This rare, hereditary disease strikes boys and men only. It primarily affects the brain and adrenal glands. Patients usually experience worsening mental deterioration, difficulty understanding or expressing language, impaired ability to handle objects, and blindness. This patient's history of ALD began at age 19 with episodes of severe fever, nausea, vomiting, diarrhea and fatigue. Adrenal insufficiency (inadequate secretion of adrenal hormones) was diagnosed from his low cortisol levels. He began taking adrenal steroid replacement medication which made him feel well. He also developed skin hyperpigmentation, appearing to have a very dark tan regardless of time spent in the sun. After approximately 15 years of maintenance with these symptoms, he developed clumsiness in his feet, began limping, and could not sense heat and cold in his feet. The physician explained that adrenal insufficiency is difficult to diagnose until symptoms become severe, since initial signs include common complaints of digestive problems and fatigue. Diagnosis of adrenal insufficiency often follows discovery of an abnormal physical sign or laboratory test result.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1989
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Adrenoleukodystrophy: New approaches to a neurodegerative disease
Article Abstract:
New insights regarding the presentation, prevention, and treatment of X-linked adrenoleukodystrophy (X-ALD) is presented. Neonatal screening is likely to become available, and a wider awareness of X-ALD and its various modes of presentation permit new proactive approaches to this distressing disorder.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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Evaluation and treatment of Chagas disease in the United States
Article Abstract:
The article reviews the evaluation and treatment of Chagas disease in the U.S. that relies on serologic methods and proper screening has to offer for patients with such exposure.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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