Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: indicators of disturbed placentation in absence of evidence of endothelial dysfunction?

Article Abstract:

Pre-eclampsia may be caused by alterations in cell adhesion molecules that affect the binding of the placenta. Altered levels of cell adhesion molecules were found in a study of 2,190 women who developed pre-eclampsia during pregnancy. Pre-eclampsia is a serious complication of pregnancy.

Health aspects, Cell adhesion molecules

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High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia

Article Abstract:

Pregnant women who eat more than 3,000 calories per day, foods high in sugar content, and greater than normal amounts of polyunsaturated fatty acids have a greater risk of developing preeclampsia than other pregnant women. This was the conclusion of a study of 3,133 pregnant women, 85 of whom developed preeclampsia during pregnancy.

Risk factors, Food and nutrition, Pregnant women

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Sera of preeclamptic women are not cytotoxic to endothelial cells in culture

Article Abstract:

There do not appear to be any substances in the blood serum of pregnant women with preeclampsia that harms endothelial cells, the cells lining blood vessels. Preeclampsia is high blood pressure during pregnancy. One of the theories of preeclampsia is that damage to these cells leads to the production of substances that cause the symptoms of preeclampsia. Endothelial cells were harvested after birth from the umbilical cord veins of babies from normal pregnancies. They were incubated with blood serum either from healthy pregnant women with normal blood pressure or with serum from preeclamptic women. No differences were found on two different tests of the cell's metabolic competency. The cells' ability to attach to a surface and form a sheet were unimpaired. No differences in appearance were seen under the microscope. No differences were found in protein synthesis rates or in DNA replication rates. Cell growth rates were similar. Other experiments have shown changes in metabolism and function among endothelial cells from women with preeclampsia, but they do not appear to be damaged.

Vascular endothelium

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