Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction

Article Abstract:

The polymerase chain reaction (PCR) may identify many cases of intra-uterine infection that biological cultures miss. In a study of 154 pregnant women with premature rupture of fetal membranes, biological culture missed 40% of the women who were infected with the bacterium Ureaplasma urealyticum.

Infection, Diagnosis, Causes of, Polymerase chain reaction, Bacterial infections, Uterus

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An increase in fetal plasma cortisol but not dehydroepiandrosterone sulfate is followed by the onset of preterm labor in patients with premature rupture of the membranes

Article Abstract:

An increased fetal plasma cortisol level in a pregnant woman with preterm rupture of membranes may predict the spontaneous onset of labor. Researchers analyzed fetal blood samples in 51 pregnant women whose fetal membranes had ruptured prematurely, but who were not in labor. The average fetal cortisol level in women who spontaneously began labor within one week of rupture was 8.35 micrograms/deciliter (mcg/dL), but only 4.75 mcg/dL in women who did not begin labor. There was no significant difference in fetal dehydroepiandrosterone levels.

Labor (Obstetrics), Fetal blood, Hydrocortisone, Dehydroepiandrosterone, Dehydroepiandrosterone sulfate

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Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments

Article Abstract:

Invasion of the amniotic cavity by Ureaplasma urealyticum provokes a significant inflammatory response in pregnant women with prematurely ruptured fetal membranes. Researchers measured inflammatory mediators in the amniotic fluid and postpartum umbilical cord blood in 120 pregnant women. Isolated Ureaplasma urealyticum microorganism invasion in the absence of other organisms was detected in 21% of women with ruptured membranes, and was associated with elevated amniotic fluid leukocyte, tumor necrosis factor, and interleukin 1-beta levels and a higher level of interleukin-6 in the umbilical cord blood. These changes are consistent with a defensive inflammatory response.

Inflammation, Inflammation mediators, Chorioamnionitis, Ureaplasma urealyticum

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