Comparison of immunologic restoration and virologic response in plasma, tonsillar tissue, and cerebrospinal fluid in HIV-1-infected patients treated with double versus triple antiretroviral therapy in very early stages: the Spanish Earth-2 study
Article Abstract:
Only triple combination therapy with two nucleoside reverse transcriptase inhibitors and a protease inhibitor suppresses HIV levels in blood, lymph gland tissue, and cerebrospinal fluid, according to a study of 94 HIV patients. Although the patients' immune systems recovered somewhat, it never recovered to its pre-infection level.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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Relevance of HIV-1-Specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3
Article Abstract:
Analysis of the dynamics of HIV-1-specific CD4+ and CD8+ T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point was achieved. It was found that STI does not help control viral replication in CHI patients and this may be due to the fact that boosted CTL responses lack strong and durable helper T-cell responses.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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Effect of Mycophenolate Mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection
Article Abstract:
A randomized pilot study was conducted to assess the role of mycophenolate mofetil (MMF) during interruption of highly active antiretroviral therapy (HAART) when 17 patients with early stage chronic HIV type 1 infection were treated with HAART for 12 months. On combining MMF and HAART delayed VL rebound and improved control of viral replication without HAART but only when inhibition of lymphocyte proliferation was achieved.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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