Analysis of nutritional intake in a cohort of homosexual men

Article Abstract:

HIV infection may cause an increase in metabolism, shown by higher rates of energy expenditure. Two hundred eighty-four gay men gave their dietary intake by describing all the food they ate, and where and when. There were 139 HIV-infected men without AIDS and 145 men who were HIV negative. The HIV-infected homosexual men had considerably higher caloric intakes than the 145 homosexual men without HIV, but they did not gain more weight. Any potential weight loss caused by HIV infection was counterbalanced by the increase in intakes of carbohydrates, fat, protein and cholesterol. A 10-kg weight gain would be expected under normal conditions as a result of the increased caloric intakes. CD4 counts had no effect on caloric intake.

Health aspects, Food and nutrition

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Improved survival among HIV-infected individuals following initiation of antiretroviral therapy

Article Abstract:

Combination drug therapy for HIV infection appears to lower mortality rates and prolong survival. Researchers followed 1,178 patients who began therapy with more than one antiviral drug between 1992 and 1996. By 1996, five drugs had been approved to treat HIV infection: zidovudine, didanosine, zalcitabine, lamivudine or stavudine. One-third of the patients died during the study. Those who were treated with combination therapy including zidovudine, didanosine or zalcitabine were about twice as likely to die and more likely to progress to AIDS as those whose treatment included lamivudine or stavudine.

Evaluation, Patient outcomes, Mortality, Drug therapy, Drug therapy, Combination, Combination drug therapy

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Performance of immunologic responses in predicting viral load suppression

Article Abstract:

Logistic regression analysis was used to calculate sensitivity, specificity, and positive and negative predictive values for immunologic responses in terms of predicting failure to achieve 2 viral load measurements <500 copies/mL within 1 year. The analysis has shown that using immunologic criteria to predict which patients have not achieved virologic suppression results in significant misclassification of therapeutic responses.

Analysis, Usage, Measurement, Immune response, Viremia, Viral load, Clinical report, Logistic curve

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