Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
Article Abstract:
A study is conducted to monitor the cell cycle in a genetically engineered, historically accurate model of glioma in vivo using bioluminescence imaging. It is suggested that the development of the Ef-luc mouse can be of great help in this process and will be a valuable tool in such in vivo explorations in the future.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Imaging 26S proteasome activity and inhibition in living mice
Article Abstract:
The approach to 26S proteasome function in living animals that led to discovery of ubiquitin-luciferase for bioluminescence imagining is illustrated. The ubiquitin-proteasome acts as a central mediator to regulate proteolysis in cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Bioluminescent imaging of Cdk2 inhibition in vivo
Article Abstract:
Several biological pathways impinge on the action of ubiquitin ligases. Arrays of reporters probing orthogonal aspects of biological space can be used to monitor actions of drug-like molecules on biological systems.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Imaging of angiogenesis: from microscope to clinic
- Abstracts: Defending the epithelium. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
- Abstracts: Dilated cardiomyopathy: learning to live with yourself. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
- Abstracts: Bacteria spurned by self-absorbed cells. [CD8.sup.+] T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes