Antibodies to DNA
Article Abstract:
The presence of antibodies against DNA is one of the characteristics of systemic lupus erythematosus (SLE). Many healthy people have antibodies to single-strand DNA but SLE patients have antibodies to double-strand DNA. They also appear to have defects in the immune system so the antibodies are not destroyed. Animal research shows that antibodies to DNA can be caused by chemicals, bacterial and viral proteins, and DNA-protein complexes. The antibodies can damage blood vessels and the kidneys. Immunosuppressive drugs are used to treat SLE but researchers hope to develop more specific drugs with fewer side effects.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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An echocardiographic study of valvular heart disease associated with systemic lupus erythematosus
Article Abstract:
Heart valve disease appears to be common in patients with systemic lupus erythematosus and can be a leading cause of death. This was demonstrated in a study of 69 people with systemic lupus erythematosus and 56 healthy volunteers. Echocardiograms revealed that 61% of the lupus patients had heart valve disease compared to only 9% of the healthy participants. The valve disease sometimes resolved and was not always associated with a worsening of lupus. Seven lupus patients died during the study, six of some type of heart disease.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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Systemic lupus erythematosus and accelerated atherosclerosis
Article Abstract:
People who have systemic lupus erythematosus (SLE) have a greater than normal risk of developing atherosclerosis, according to two studies published in 2003. Therefore, doctors should counsel these patients to eliminate other risk factors for cardiovascular disease, such as obesity, high blood pressure, high cholesterol levels, and smoking. SLE may cause atherosclerosis by increasing inflammation in the body.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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