Assessment of fetal activity and amniotic blood fluid volume in the prediction of intrauterine infection in prelabor amniorrhexis

Article Abstract:

Infection inside the pregnant uterus after a premature rupture of the amniotic sac may not be accurately predicted by currently used measures. Researchers assessed 89 women with preterm rupture of the amniotic sac before they went into labor. Infection was detected by taking blood samples from the umbilical vein and fluid samples from amniotic fluid. Samples were analyzed for the presence of various infectious organisms. The currently used measures of fetal heart rate pattern, biophysical profile score (fetal activity), and amount of amniotic fluid did not accurately predict intrauterine infection. In mothers in whom infection was diagnosed, there was no correlation with fetal and amniotic fluid measures. Fetuses were receiving enough oxygen, so their heart rate patterns were not abnormal. The fetal activity score changed as pregnancy advanced, and differences between infected and uninfected women were not noted.

Infection, Complications and side effects, Premature labor, Uterus

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Fetal plasma interferon gamma concentration in normal pregnancy

Article Abstract:

Levels of fetal interferon gamma may be significantly higher during the first trimester of pregnancy. Interferon gamma is a glycoprotein with immunological activity against different types of viruses. Levels of interferon gamma were measured in blood samples from 54 fetuses that were between 12 and 37 weeks old. Fetal blood levels of interferon gamma were almost 2 1/2 times higher at week 12 than at week 37. Interferon gamma may play an important role in the early immunological system of the fetus. Measurement of fetal blood levels of interferon gamma may help in the prenatal diagnosis of different types of infections.

Interferon gamma

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Plasma adenosine responses during repeated episodes of umbilical cord occlusion

Article Abstract:

Adenosine appears to play a role in fetal oxygen regulation and protection during periods of low oxygen supply. Blood levels of adenosine were monitored in five fetal sheep as oxygen supply through the umbilical cord was repeatedly blocked and released. Adenosine levels increased from baseline levels of 0.82 micromoles per liter (micromol/L) to a maximum of 1.31 micromol/L after 20 blockage and release cycles. When the 20 cycles were repeated one hour later adenosine levels again increased but not higher than during the previous cycle set. Adenosine levels later returned to baseline levels.

Oxygen, Oxygen in the body, Adenosine

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