Association of two loci on chromosome 2q with nodal osteoarthritis
Article Abstract:
There may be a link between sections of chromosome 2 and the progression and transmission of nodal generalized osteoarthritis (NOA). Researchers tested white blood cells from 99 siblings with NOA to identify common chromosome sections. A significant number of siblings with NOA had two sections of chromosome 2 that code for three genes important to the NOA disease process. These genes code for part of an important bone component called collagen type V, a cartilage protein called fibronectin, and an immune protein called interleukin-8. The siblings did not share a characteristic chromosome section close to the section that codes for the immune complexes called the human leukocyte antigen system.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Radiographic assessment of patellofemoral osteoarthritis
Article Abstract:
The 'skyline view' may be more sensitive than the lateral view for radiographic assessment of patellofemoral osteoarthritis. Osteoarthritis is a noninflammatory joint disease that mainly occurs in older individuals. The patellofemoral joint is the joint between the knee cap and the thigh bone. X-rays were taken from the skyline and lateral views of both knees of 20 patients between 18 and 91 years old with osteoarthritis of the knee. Radiographic grading of X-rays taken from the skyline view was more reproducible than grading of X-rays taken from the lateral view. X-rays taken from the skyline view were also more sensitive for evaluating joint space narrowing over a wider range of categories.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
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Clinical features and outcome of septic arthritis in a single UK Health District, 1982-1991
Article Abstract:
Specific diagnosis of septic arthritis is crucial, as it is a major source of sickness and death, and therefore samples of synovial fluid and blood for culture should be drawn before beginning antibiotic treatment. Septic arthritis is bone inflammation caused by bacterial pathogens. In a study reviewing all patients admitted to a hospital between January 1, 1982 and December 31, 1991 with confirmed septic arthritis, outcomes included death, osteomyelitis and functional physical impairment. Staphylococcus aureus or streptococci were responsible for 74% of the cases, and many of the rest were gonoccocal infections.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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