BRCA1 and BRCA2
Article Abstract:
A task force convened by the Cancer Genetics Studies Consortium has published recommendations for women who carry the BRCA gene mutations. Mutations in the BRCA1 and BRCA2 genes have been linked to familial breast and ovarian cancer. Women who test positive for the mutations should begin breast self-examination at age 18-21 and should have annual mammograms and physician exams at age 25-35. Annual screening for ovarian cancer should include transvaginal ultrasound and testing for the CA-125 tumor marker. There is no evidence that removing the breasts or ovaries can prevent the development of cancer.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer
Article Abstract:
The relationship between race and the use of BRCA1/2 counseling among women with a family history of breast or ovarian cancer is investigated. Results revealed large racial disparities where among women with a family history of breast or ovarian cancer, women who underwent BRCA1/2 counseling (cases) were significantly less likely to be American than women who did not undergo BRCA1/2 counseling.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both
Article Abstract:
Women with a mutation in the BRCA1 gene may be more likely to give birth to girls than boys, according to a study of 68 families with a history of breast or ovarian cancer. BRCA1 gene mutations have been linked to some types of hereditary breast or ovarian cancer. This study shows that they may also cause more girls to be born than boys.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
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