Benign gynecological conditions among participants in the Breast Cancer Prevention Trial

Article Abstract:

A study was undertaken to report on the benign gynecologic conditions occurring among women with an intact uterus at enrolment in the Breast Cancer Prevention Trial of the National Surgical Adjuvant Breast and Bowel Project. The results supported the estrogen agonist role of tamoxifen as the causative factor for the increased risk of endometrial polyps, leiomyomas, endometriosis, and endometrial hyperplasia among women taking this agent.

Care and treatment, Diagnosis, Complications and side effects, Estrogen, Tamoxifen (Medication), Familial Mediterranean fever, Periodic disease, Estrogen antagonists

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Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: The NSABP study of tamoxifen and raloxifene (STAR) P-2 trial

Article Abstract:

A study is conducted to compare the differences in patient-reported outcomes, quality of life (QOL) and symptoms in Study of Tamoxifen and Raloxifene (STAR) participants by treatment assignment. The results reveal that no significant differences existed between the tamoxifen and raloxifene groups in patient-reported outcomes for physical health, mental health and depression, although the tamoxifen group reported better sexual function.

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Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes

Article Abstract:

A study is conducted to compare the relative effects and safety of raloxifene and tamoxifen on the risk of developing invasive breast cancer and other disease outcomes. The results reveal that raloxifene is as effective as tamoxifen in reducing the risk of invasive breast cancer and has lower risk of thormboembolic events and cataracts but nonstatistically significant higher risk of noninvasive breast cancer.

Drug therapy

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