Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Article Abstract:
Blockade of the mitogen-activated protein (MAP) kinase pathway has been found to suppress growth of colon tumors. A highly potent and selective inhibitor of the orally active upstream kinase MEK has been found. Tumor growth was inhibited as much as 80% in mice with colon carcinomas of both mouse and human origin after treatment with the inhibitor.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
Article Abstract:
Mice lacking in tumor necrosis factor-alpha (TNF-alpha), which is a pro-inflammatory cytokine, have been found to be resistant to skin carcinogenesis. Neutralizing TNF-alpha production is potentially useful in cancer treatment/prevention, but has little influence on later carcinogenesis stages.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Dengue virus and dendritic cells
Article Abstract:
Research presented concerns the function of dentritic or antigen-presenting cells, focusing on their role in the pathogenesis of the Dengue virus. Topics addressed include the regulation of immune responses to Dengue virus infection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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