Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

Article Abstract:

Mutation of the cyclin-dependent-kinase inhibitor 2 (CDKN2) gene may lead to the development of pancreatic cancer. The CDKN2 gene is believed to be a tumor-suppressor gene. A 34-year-old woman, with three maternal relatives who had died of pancreatic cancer, developed tongue carcinoma. Researchers analyzed the DNA from the woman, and from several of her relatives. The woman and her relatives who had pancreatic cancer all had the same mutation of the CDKN2 gene and another gene marker. Members of her family who did not have cancer had neither the mutation nor the same gene marker. This familial gene pattern suggests that the CDKN2 gene is involved in the development of melanoma and pancreatic carcinoma.

Pancreatic cancer

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Cancer regression by senescence

Article Abstract:

Researchers have found that a cancer with functional p53 responds to a p53-targeted therapy by undergoing apoptosis or senescence, where the apoptotic and senescent cells are recognized and phagotytosed by macrophages, resulting in regression of the tumor. The analysis has provided an alternative mechanism to cell death that explains cancer regression and has indicated that senescence is a relevant outcome of anticancer therapies.

Cancer regression, Apoptosis

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Distinct sets of genetic alterations in melanoma

Article Abstract:

Genome-wide alterations were compared in the number of copies of DNA and mutational status of BRAF among the four groups of melanomas with an aim of signaling pathways that are markedly altered in melanoma. Results reveal significant differences in the frequencies of regional changes in the number of copies of DNA and mutation frequencies in BRAF among the four groups of melanomas.

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