Cancer: The matrix is now in control
Article Abstract:
The idea that the extracellular matrix (ECM) has a subsidiary function in cancer development and provide compelling evidence that the tumor microenvironment could have an active role in the initial steps of epithelial tumorigenesis is presented. The ECM is a complex molecular milieu that provides cells with the tensile scaffold necessary for appropriate assembly into three-dimensional macroscopic structures.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Article Abstract:
The study report that heme oxygenase-1 (OH-1) prevents the development of experimental cerebral malaria by mediating binding of CO to hemoglobin which prevents the hemoglobin oxidation and the generation of free heme, a molecule that triggers experimental cerebral malaria pathogenesis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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