Carcinogenicity of lipid-lowering drugs

Article Abstract:

Many cholesterol reducing drugs cause cancer in rodents and should be used only in humans with a high risk of dying of coronary heart disease in the near future. Researchers reviewed data in the 1992 and 1994 editions of the "Physicians Desk Reference" on drugs used for lowering cholesterol levels and those for lowering blood pressure. All of the lipid-lowering drugs classified as fibrates and statins caused cancer in rodents. Some of these drugs caused cancer in rodents at doses that are close to those give to humans. Of the antihypertensive drugs, only 15% caused cancer in rodents. Applying such animal test results to human beings is controversial. More research and time are required to assess the long-term risks of cholesterol reducing drugs. However, research suggests that long-term, preventative use of these drugs on patients without arterial disease should be avoided. Niacin and cholestyramine may be less carcinogenic than fibrates and statins, but tend to have unpleasant side effects.

Complications and side effects, Risk factors, Carcinogenesis, Antilipemic agents

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Management and outcomes of care of fever in early infancy

Article Abstract:

A clinical prediction model is developed to characterize the management and clinical outcomes of fever in infants, for the identification of bacteremia/bacterial meningitis, and compare the accuracy of various strategies. Pediatric clinicians in the United States use individualized clinical judgment in treating febrile infants, however, relying on clinical guidelines is not improving care but resulting in more hospitalizations and laboratory testing.

United States, Science & research, Care and treatment, Research, Pediatric diseases, Fever in children, Childhood fever

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Gender differences in physician-patient communication: evidence from pediatric visits

Article Abstract:

Female pediatricians may take more time during examinations of children, and provide care more satisfying to the parents. Researchers examined videotapes of doctor visits by 212 children. Female physicians spent 29% more time with their patients, communicated more, and were more sociable than male physicians. Children preferred to see a doctor of the same gender, but parents were more satisfied with the care provided by female physicians.

Evaluation, Physician and patient, Physician-patient relations, Demographic aspects, Women physicians, Pediatricians

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