Cardiorespiratory responses to aerobic training by patients with postpoliomyelitis sequelae
Article Abstract:
Poliomyelitis (polio) is the second leading cause of residual paralysis in the U.S. There are an estimated 400,000 polio survivors (with various degrees of paralysis) who are at risk for developing a new constellation of problems which are called the postpolio sequelae. Now, more than 30 years after the near eradication of polio within the U.S., many survivors are reporting the following symptoms: fatigue after minimal physical activity; joint and muscle pain; progressive muscular weakness; new respiratory difficulties (including sleep apnea, short periods of breathing cessation during sleep); and intolerance to cold. Treatment of this complex of symptoms by means of exercise presents a new challenge for the medical community, because irreversible muscle damage can result from overuse of muscles operating at total capacity. The current study of the cardiovascular response of 16 patients with postpoliomyelitis sequelae to a 16-week aerobic exercise program shows that this procedure is a safe, short-term one and that these patients responded well, as would any healthy adult population, to physical training. The aerobic program exercised patients at 70 percent of maximal heart rate. Various dependent physiologic variables including resting maximal heart rate, systolic and diastolic blood pressures, maximum oxygen consumption and carbon dioxide consumption, respiratory quotient and volumetric measurements (measure amount of air moved) were considered in this study. The exercised group exceeded a control group in exercise time, watts, maximum expired volume per unit time and maximum oxygen consumption. No loss of leg strength or other negative event resulted from the exercise regimen.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1989
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Comparison of two methods to detect publication bias in meta-analysis
Article Abstract:
Egger's regression test, often used to help detect publication bias in meta-analysis, is being compared with a regression test based on sample size with InOR as the summary estimate. The alternative regression test can be used in place of Egger's regression test when summary estimates are in lnOR because of appropriate type 1 error rates and reduction in the correlation between the lnOR and its variance.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation
Article Abstract:
A study is presented to determine whether hypobaric hypoxia, which may be encountered during air travel, activates hemostasis. The findings do not support the hypothesis that hypobaric hypoxia, of the degree that might be encountered during long-haul air travel, is associated with prothrombotic alterations in the hemostatic system in healthy individuals at low risk of venous thromboembolism.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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