Cell line system should help clarify pathogenic role of viral IL-6

Article Abstract:

A growth-promoting activity for human herpesvirus type-8-derived (HHV-8) interleukin-6 (IL-6) on human myeloma cells is described for the first time. Testing of the ability of a recombinant protein of HHV-8 IL-6 to bind to and promote proliferation of the human myeloma cell line INA-6 was conducted by Renate Burger and colleagues at the University of Erlangen-Nuernberg in Germany. The team found that INA-6 is heavily dependent on exogenous IL-6 for growth and survival, with the latter substantially promoting DNA synthesis of INA-6 cells. These results should help clarify the role of IL-6 in the pathogenesis of diseases associated with HHV-8.

Genetic aspects, Herpesviruses, Carcinogenesis, Cell lines, Interleukin-6, Multiple myeloma

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Rising antigenemia does not always warrant alternative antiviral

Article Abstract:

Alternative antiviral drugs for solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, based solely on increasing antigenemia levels, are not recommended. A study conducted by Giuseppe Gerna and colleagues at the IRCCS Policlinico San Matteo in Pavia, Italy found that the earlier initiation of treatment in solid-organ transplant patients with primary HCMV infection may be followed by a significant increase in antigenemia level during the first week of treatment, slower clearance of the virus from blood or a higher incidence of secondary HCMV episodes after treatment is stopped.

Drug therapy, Organ transplant recipients, Cytomegalovirus infections, Dosage and administration, Drug use, Antiviral agents

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HVS transforms human T-cell clones by cellular activation pathway

Article Abstract:

Herpesvirus saimiri is an oncogenic virus related to the human herpesvirus that has the ability to change human T cells via the normal cellular activation pathways but not through apoptosis resistance. Although the transformed and uninfected cells failed to exhibit any reaction to apoptosis, both displayed sensitivity to CD95 ligation. However, both cells showed identical reactivity to inhibition of T cell activation.

Cell death, T cells, Herpesvirus diseases, Herpesvirus infections

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