Characterization of an antigen shared by human thymic epithelium and human T cell leukemia virus p19 gag protein
Article Abstract:
Human thymus tissue appears to share an antigen also present in human T cell leukemia virus type I (HTLV-I). HTLV-I is a retrovirus that is related to the virus that causes AIDS. Researchers tested samples of thymus tissue with monoclonal antibodies against the HTLV-I p19 protein. One antibody reacted with several low-molecular-weight keratin molecules in a thymus tissue sample from a boy undergoing heart surgery. The same antibody reacted against an amino acid sequence in the HTLV-I p19 protein. There is no clinical evidence that HTLV-I-infected people are producing antibodies against their thymus gland. However, the thymus is involved in the maturation of T cells and autoantibodies against the thymus could affect T cell development.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Delineation of immunodominant epitopes of human T-lymphotropic virus types I and II and their usefulness in developing serologic assays for detection of antibodies to HTLV-I and HTLV-II
Article Abstract:
There are major regions on several proteins produced by the human T-lymphotropic viruses I and II (HTLV-I and HTLV-II) that can stimulate the production of antibodies in humans. These antibodies could be the basis of blood tests for detecting the virus in blood samples. The major regions in both viruses include the central region of the gp46env protein, the central region of the p21e protein and the carboxyl terminus of the p40tax protein. Each virus also has unique regions not shared by the other. HTLV is transmitted by blood, so accurate blood tests could be used to screen blood.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappaB induction
Article Abstract:
The Tax protein of the human T-cell lymphotropic virus type I (HTLV-I) appears to bind to the human proteasome. The proteasome is a structure composed of stacked rings that degrades proteins. Researchers have found that the Tax protein binds to the HsN3 subunit of the proteasome. This could increase the degradation of certain proteins involved in maintaining cell cycles. This in turn would cause the proliferation of T cells, which could explain how HTLV-I causes adult T-cell leukemia.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Characterisation of anticytoplasmic antibodies and their clinical associations. Rheumatoid factors: where are we now?
- Abstracts: Relationship between serum lipids and dietary and non-dietary factors in a Chinese population. Assessment of sodium and potassium in processed foods in an urban area in China
- Abstracts: Carbon monoxide poisoning at an indoor ice arena and bingo hall - Seattle, 1996. Carbon Monoxide Poisoning Associated With Use of LPG-Powered (Propane) Forklifts in Industrial Settings--Iowa, 1998
- Abstracts: The role of fibre in the treatment of secondary hyperlipidaemia in nephrotic patients. Effect of dietary fibre on weight correction after modified fasting
- Abstracts: Cardiac pacing. Interference with cardiac pacemakers by cellular telephones. Cardiac pacemakers and cellular telephones