Comparison of E-test with agar dilution methods in testing susceptibility of N. gonorrhoeae to azithromycin

Article Abstract:

Gonorrhea may be treatable with azithromycin, and the level of azithromycin required to treat gonorrhea may reliably be determined with a new test for antibiotic susceptibility. Researchers compared the accuracy of two tests for antibiotic susceptibility, the standard agar dilution method and the new E-test, for determining the level of azithromycin required to treat specific strains of Neisseria gonorrhoeae. All 135 gonorrhea strains were found to be susceptible to azithromycin. The E-test results were similar to those of the agar dilution method in identifying the antibiotic susceptibilities of the gonorrhea strains.

Physiological aspects, Drug therapy

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Kinetics of Chlamydia trachomatis clearance in patients with azithromycin, as assessed by first void urine testing by PCR and transcription-mediated amplification

Article Abstract:

A single dose of azithromycin appears to be effective in curing patients with Chlamydia trachomatis infection. Researchers used the polymerase chain reaction (PCR) to test urine samples for chlamydia every day for seven days after 19 people with the infection were treated with a one-gram single dose of azithromycin. The percentage of urine samples that tested positive dropped substantially and by the seventh day, none tested positive. Using this test on urine samples is a noninvasive method for diagnosing chlamydia and assessing treatment results.

Health aspects, Analysis, Testing, Chlamydia trachomatis, Urine, Urinalysis

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False-positive enzyme immunoassay test results for Chlamydia trachomatis because of contact of the collection swab with agar

Article Abstract:

Testing for chlamydia and gonorrhea using a single collection swab may produce a false-positive test result for chlamydia. Both sexually transmitted diseases require tests using tissue collected from the urethra by a swab. The test for gonorrhea includes the innoculation of an agar plate for growing the bacterium. The agar deposited on the swab may contaminate the test solution used for chlamydia testing, producing an incorrect positive result. Two collection swabs should be used when testing for both diseases.

Sexually transmitted diseases, Methods, Diagnosis, Causes of, Sexually transmitted disease diagnosis, Medical screening, Health screening, Chlamydia, False positive reactions

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