Expression of two mucin antigens in cultured human ovarian surface epithelium: influence of a family history of ovarian cancer
Article Abstract:
Ovarian cells from women with family histories of ovarian or breast cancer behave differently in culture compared with cells from women without such a history. Cell samples of the ovarian outer layer were obtained from women having gynecologic surgery for nonmalignant problems. Eighteen women had no parents, siblings, or children with breast or ovarian cancer, five women had a family history but were not believed to have hereditary cancer, and seven women had a strong family history of cancer. Cells were analyzed for the cancer marker CA 125 and examined under the microscope. CA 125 production declined markedly in successive generations of cells in women with no family history or a minor family history but remained the same in women with a family history. Cells from women with no family history transformed from skin-like cells to connective tissue-like cells, whereas cells from women with a strong history maintained their skin cell-like appearance and women with a weak family history fell in between.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 expression in human amnion mesenchymal and epithelial cells
Article Abstract:
The main source of substances which maintain the integrity of amniotic membranes during pregnancy may be two types of cells in the amniotic membrane. Researchers obtained human placentas and fetal membranes after delivery of 15- to 43-week pregnancies and measured levels of tissue inhibitor of metalloproteinase (TIMP) types 1 and 2 in amnion tissue and in epithelial and mesenchymal cells of the amniotic membrane. Higher expressions of TIMP-1 were found in mesenchymal cells, while TIMP-2 was found in both mesenchymal and epithelial cells. Levels of mesenchymal cells in amnion are reduced in term placentas.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Regulation of metallothionein expression in human amnion epithelial and mesenchymal cells
Article Abstract:
Cadmium from cigarette smoke may affect the organization of collagen in fetal membranes and increase the risk of premature membrane rupture in pregnant women who smoke. Researchers tested the effect of cadmium on cells from human amnion membranes. Levels of metallothionein in amniotic cells increased significantly when the cells were exposed to cadmium. Metallothionein is a peptide that binds metals such as copper, which is used in an enzyme system involved in collagen cross-linking in amniotic tissue. Cross-linked collagen contributes to the strength of fetal membranes.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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