Comparison of endometrial growth produced by unopposed conjugated estrogens or by micronized estradiol in postmenopausal women

Article Abstract:

Half-strength estradiol hormone replacement therapy may cause half as much thickening of the uterine lining as full strength therapies. Researchers studied the effect of full- and half-strength micronized estradiol and of conjugated estrogen hormone replacement therapies lasting 24 weeks in 87 postmenopausal women. Full-strength estradiol and conjugated estrogen were associated with twice as much thickening of the uterine lining and with more scheduled and unscheduled uterine bleeding than was half-strength estradiol. Use of full-strength, unopposed estrogen for long periods, such as 24 weeks, may need to be questioned.

Growth, Endometrium

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Effects of hormone replacement therapy on the endometrium and lipid parameters: a review of randomized clinical trials, 1985 to 1995

Article Abstract:

A review of 48 clinical trials of hormone replacement therapy confirms that progesterone can offset the adverse effects of estrogen and combined hormone therapy can also lower blood cholesterol levels. Estrogen alone can increase the risk of endometrial cancer, but this effect is prevented by progesterone. Estrogen alone and estrogen plus progesterone also lower total cholesterol and LDL, or 'bad', cholesterol, while increasing HDL, or 'good', cholesterol. Cholesterol levels often rise following menopause and hormone therapy appears to reverse this process. This would lower the woman's risk of cardiovascular disease.

Health aspects, Prevention, Estrogen, Estrogens, Hypercholesterolemia, Endometrial hyperplasia

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Serum and tissue hormone levels of vaginally and orally administered estradiol

Article Abstract:

Giving women estradiol via a vaginal suppository leads to higher levels of estradiol in the blood and uterus compared to a pill taken orally. Estradiol is not absorbed very well when taken orally. Vaginal estradiol could also be used for hormone replacement therapy.

Statistical Data Included, Evaluation, Vagina, Medication by, Vaginal medication

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