Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
Article Abstract:
Research presented concerns the dynamics of HIV infection after the use of highly active anti-retroviral therapy by HIV patients. Topics addressed include how the latent viral reservoir affects CD4 T cells and rebounding plasma viremia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes
Article Abstract:
A model of HIV virus progression in rhesus monkeys is presented, focusing on the difficulties of achieving an antibody or immunological response to HIV-1 envelope proteins. Rhesus macaques were immunized with phage-displayed epitopes and evaluated for protection levels from viral challenge.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Effect of interleukin-2 on the pool of latently infected, resting CD4(super.+) T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
Article Abstract:
Intermittent administration of interleukin (IL)-2 with continuous highly active anti-retroviral therapy (HAART) may lead to a substantial reduction in the pool of resting CD4(super.+) T cells containing replication-competent HIV. In a recent study it was found that virus could not be isolated from the peripheral blood CD4(super.+) T cells in three patients receiving IL-2 plus HAART. The size of the pool of resting CD4(super.+) T cells containing replication-competent HIV in the blood of patients receiving intermittent IL-2 plus HAART was significantly lower than that of patients getting only HAART.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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