Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
Article Abstract:
Vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein has been found in a study to be safe and effective. It brings on a broad, specific immune response (both humoral and cellular), lowers infection with simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels and thereby prevents the CD4+ T-cell decrease. For HIV vaccine development, blocking virus entry seems less likely to succeed than controlling viral infection and blocking disease onset.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Therapeutic dendritic-cell vaccine for simian AIDS
Article Abstract:
Research demonstrates that inactivated whole virus-pulsed dendritic cell vaccines are effective in controlling the immunodeficiency virus caused diseases. Results indicate that simian immunodeficiency virus-infected rhesus monkeys develop a durable virus-specific cellular and humoral immunity upon vaccination with chemically inactivated and virus-pulsed dendritic cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: applications for universal detection and quantitation
Article Abstract:
The multiple-primer-induced overlapping amplification assay MUPROVAMA can detect many different genotypes of HIV and may be useful in measuring viral load. The assay and its effectiveness are described.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
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