Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia

Article Abstract:

Tailoring chemotherapy to a child's metabolic rate may improve prognosis in children with certain types of acute lymphoblastic leukemia. Children metabolize drugs differently and those who metabolize drugs quickly may not benefit as well from chemotherapy. Researchers randomly assigned 182 children with acute lymphoblastic leukemia to receive chemotherapy based on their body surface area or on their metabolic rate. Tailoring the drug dosage to the metabolic rate improved prognosis, but only in children with leukemia of the B cell line.

Health aspects, Dosage and administration, Chemotherapy, Drug metabolism, Lymphoblastic leukemia in children, Childhood leukemia

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Acute lymphoblastic leukemia

Article Abstract:

Researchers continue to look for promising treatments for acute lymphoblastic leukemia. This form of leukemia usually strikes children and cure rates are almost 80%. Adults have a poorer prognosis, with cure rates around 30% to 40%. Treatment consists of multi-drug chemotherapy. Stem cell transplants and gene therapy are two possible options. Many patients also have metabolic abnormalities that need to be corrected. Various factors can be used to classify patients at high, average, or low risk of relapsing.

Analysis, Lymphocytic leukemia

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Treatment of acute lymphoblastic leukemia

Article Abstract:

The latest advances in the treatment of acute lymphoblastic leukemia (ALL) are described, emphasizing issues that must be addressed if treatment outcome is to improve further. Age and leukocyte count at diagnosis continue to be strong prognostic indicators of outcome, mainly among patients with B-cell precursor ALL.

United States, Care and treatment, Diagnosis, Prognosis

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