Design and use of conditional MHC class I ligands

Article Abstract:

Conditional major histocompatability complex (MHC) ligands for the generation of peptide-receptive MHC class I molecules are identified. Arrays of peptide ligands loaded onto empty MHC molecules help in the determination of MHC binding properties and for monitoring antigen-specific T-cell responses in high-throughput manner.

Peptides, Histocompatibility, Atomic properties

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Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

Article Abstract:

Therapeutic neutralization of CD95 ligand significantly decreased apoptotic cell death after spinal cord injury (SCI). The improvement in function was due to an increase in regenerating fibers and upregulation of growth-associated protein-43 (GAP-43).

Spinal cord injuries

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NF-(kappa)B is activated and promotes cell death in focal cerebral ischemia

Article Abstract:

NF-(kappa)B has been found to be activated and to promote cell death in focal cerebral ischemia. In a rodent model of stroke, the role of NF-(kappa)B has been studied. NF-(kappa)B may provide a new pharmacological target in neurologic disease.

Germany, Physiological aspects, Stroke (Disease), Stroke, Cell death, Rodents, Cerebral ischemia

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