Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease
Article Abstract:
Epstein-Barr virus (EBV) DNA has been found in biopsy tissues of about 20 percent of patients with Hodgkin's disease. Tissue samples from 16 patients with EBV DNA were studied in an effort to determine which cells contain the EBV genomes. One theory was that EBV DNA might reflect an increase in EBV-infected B cells due to the diminished immune competence in patients with Hodgkin's disease; the other theory was that EBV genomes might be located within the Reed-Sternberg cells and variants which are associated with the neoplastic element of Hodgkin's disease. Various hybridization techniques were used to investigate the presence of EBV genoomes. It is concluded that EBV genomes and variants are present within the Reed-Sternberg cells and variants and that the infected cells are monoclonal. It appears that a subset of patients with Hodgkin's disease has an increase in EBV-infected cells, but the reasons for this mechanism and the origin of the Reed-Sternberg cells are not known.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1989
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New therapies for Fabry's disease
Article Abstract:
Two therapies for Fabry's disease illustrate how treatment can be tailored to an individual patient. Fabry's disease is caused by an enzyme deficiency, which can be treated by replacing the enzyme. It can also be treated by giving patients more of the enzyme's substrate, which might stabilize the enzyme so it can work better.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
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Graves' disease
Article Abstract:
The causes, risk factors, symptoms, diagnosis, and treatment of Graves' disease are reviewed. Graves' disease is a form of hyperthyroidism, which means the thyroid gland produces too much thyroid hormone. In Graves' disease, this is caused by autoantibodies that stimulate the thyroid gland.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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