Direct visualization of antigen-specific cytotoxic T cells - a new insight into immune defenses

Article Abstract:

A chemically synthesized compound that looks like an HLA molecule bound to a foreign peptide can be used to directly measure T cells that are targeted to a specific peptide. HLA molecules are molecules that present foreign peptides to T cells so the T cell can kill the organism that produced the peptide. The synthetic version will still bind to T cells that recognize the synthetic peptide. It can be labelled with a fluorescent chemical so the T cells can be counted. This technique can precisely measure the immune response to a specific organism. However, the structure of the peptide must be known.

Measurement, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, CD8 lymphocytes

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The hypereosinophilic syndrome and the biology of cancer

Article Abstract:

Some cases of a disease called hypereosinophilic syndrome have a molecular abnormality similar to the one that causes chronic myelogenous leukemia (CML). The molecular abnormality is an enzyme created by a chromosome abnormality. Because the enzyme is similar to the enzyme that causes CML, this type of hypereosinophilic syndrome can be successfully treated with Gleevec.

Genetic aspects

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Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis

Article Abstract:

A drug called mepolizumab may benefit patients with a skin disease called eosinophilic dermatitis, according to a study of three patients. This drug is a monoclonal antibody against interleukin-5, which is produced in greater than normal amounts in these patients. The drug may benefit patients who do not respond to other drugs used for this disease.

Product information, Sweden, Pharmaceutical industry, Skin, Dermatitis, GlaxoSmithKline AB

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